We couldn't have managed any of our research in Shetland or Orkney without our volunteers. Here you can read about what we've achieved thanks to their help. Actionable genetic variants in 4,198 Scottish participants from the Orkney and Shetland founder populations and implementation of return of results Pioneering genetics study outlines practical and ethical pathway to return actionable results to volunteers and identifies ten genetic variants which have become common enough to warrant population screening. 67 harmful genetic variants enriched in different UK regions Research, including data from 4,000 ORCADES and Viking Health Study – Shetland volunteers, has found 67 regionally enriched genetic variants across the UK that cause disease. Two founder variants account for 90% of pathogenic BRCA alleles in Orkney and Shetland Viking Health Study - Shetland (VIKING I) volunteer data has linked a harmful variant in the gene BRCA2 to a historic origin in Whalsay, Shetland. The genetics of brain-related proteins and their relationship to behaviour and psychiatric disorders International collaboration identifies hundreds of proteins in human blood related to human behavioural traits and psychiatric disorders. ORCADES volunteer data helps researchers to understand the positive and negative role of proteins in Multiple Sclerosis (MS) Researchers find a protein called lymphotoxin-alpha may play role in Multiple Sclerosis (MS). Viking II, a worldwide study of volunteers with ancestry from the Northern Isles of Scotland Methodology of genetically distinct cohort study shows pathway for genomic medicine in population health. A practical checklist for return of results from genomic research Viking Genes' pioneering work helps European researchers to propose pathway checklist for return of genetic results to research participants. Cancer risk gene variant discovered in Orkney Orkney Complex Disease Study (ORCADES) volunteer data has helped to link a variant in the gene BRCA1 to a historic origin in Westray, Orkney. This article was published on 2024-01-25
